- Daniel “Danny” Ernest Tanner (played by Bob Saget) - He is the co-host of the morning talk show Wake Up, San Francisco, along with Rebecca Donaldson, who later becomes his sister-in-law. Danny is best known for his obsession with talking and cleaning. In the later seasons, Danny seeks out a potential wife, and at one point is engaged to Vicky, but that ended as she moved across the country to pursue her career in broadcasting. He is sometimes annoyed with Becky’s surprises that she tricks him into on their talk show.
- (Hermes) Jesse Katsopolis (played by John Stamos) Danny’s brother-in-law, who is an up-and-coming musician. He eventually marries Rebecca Donaldson, and has twin boys, Nicky and Alex. Early in the series, he was known as Jesse Cochran. He is known to be obsessed with his hair and Elvis Presley, and rides a Harley-Davidson motorcycle. His catchphrase, usually when he kisses or meets a beautiful woman, is “Have mercy!” Throughout the seasons, Jesse makes some special musical appearances with The Beach Boys, who he claims are long-time friends of his.
- Joseph “Joey” Alvin Gladstone (played by Dave Coulier) - Danny’s best friend through grade school and college. He moves in to help Danny with his three girls. He makes a living primarily as a comedian. He is also known for his imitations of cartoon characters including Popeye and Bullwinkle the Moose. He is also the puppeteer behind the lovable Mr. Woodchuck. But he quit after he was replaced, Joey and Jesse co-hosted the radioshow Rush Hour Renegades. His catchphrase is “Cut..It..Out!”, accompanied by hand gestures.
- Donna Jo “D.J.” Margaret Tanner (played by Candace Cameron Bure) - Oldest daughter in the Tanner household, who is a typical teenager, into fashion, boys, and her struggle for independence and privacy while living in the bustling Tanner household. She has two occasional catchphrases, “Whoa, baby!” and “Oh, mylanta!”. She was born on February 9, 1977.
- Stephanie Judith Tanner (played by Jodie Sweetin) - Middle daughter of the Tanner household. She is known to have an energetic and talkative personality. She also has three catchphrases: “How rude!”, “Well, pin a rose on your nose,” and “Hot dog!” She was born on January 14, 1982.
- Michelle Elizabeth Tanner (played by Mary-Kate and Ashley Olsen) - Youngest of the Tanner daughters. Her first word was cookies. She has a strong bond with Jesse, who refers to her with the nicknames “Shortie”, “Munchkin”, “Rugrat”. She also has a strong bond with Joey, who worked his way into her heart with the lovable Mr. Woodchuck. Michelle has her own catchphrases: “You got it, dude!”; “You’re in big trouble, Mister!” and “Aww nuts”. In the first few seasons, Michelle was also obsessed with Big Bird. She was born on November 12, 1986.
- Rebecca “Becky” Donaldson-Katsopolis (played by Lori Loughlin) - Co-hosts the morning show Wake Up, San Francisco with Danny. Introduced in the second season, Becky dates Jesse for about two years before becoming his wife, and in the fifth season she gives birth to twin sons Nicky and Alex. By the eighth season, Becky has been named as producer of Wake Up, San Francisco. She is known for her witty jokes and unexpected surprises (usually embarassing) towards Danny.
- Kimberly Louise Gibbler (played by Andrea Barber) - D.J.’s best friend and next-door neighbor, who usually serves as a punchline while visiting the Tanners’ home. She is known for her lack of a “fashionable” wardrobe. She is also known for her stinky feet and eccentric family. Kimmy also has been known to have quite a wild side at times. An interesting note is that Kimmy in season one is said to have three sisters but later on in the series she says that she only has an older brother. Although she has proven to be ditzy and brain-dead, she has a sweet and kind heart. She actually one time paired up with Stephanie to help her with a problem, even though in almost every episode, they are seen making fun of each other.
- Steve Hale (played by Scott Weinger) - He was originally introduced in season five as Steve Peters. He was D.J.’s steady boyfriend for two years. He began dating D.J. during her trip to Spain. He is quite athletic, most notably as the captain of his high school wrestling team. He is also known for his immense appetite, as he is constantly eating large amounts of food in the Tanners’ kitchen during his visits. He came back for the very last episode as D.J.’s date for her prom.
- Nicholas “Nicky” and Alexander “Alex” Katsopolis (played by Blake and Dylan Tuomy-Wilhoit) - Identical twin sons of Jesse and Rebecca, born in the fifth season. Nicky was named after Jesse’s father, and Alex was named after one of Rebcca’s old professors With Jesse and Rebecca already living in the Tanners’ apartment-sized attic, the boys are also raised there, and bringing the household head-count to 9 people. They were born on Michelle’s 5th birthday, thus cutting her party short. They are very mischievous and are well known for laughing at Joey’s jokes.
- Comet Tanner - The golden retriever adopted by the Tanners. Daughter of Minnie.
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